What is Wolff-Parkinson-White Syndrome?

Wolff-Parkinson-white Syndrome, or WPW, is characterized by electrical abnormalities of the heart that are caused by electrical conduction over an accessory-wide pathway (a microscopic, hair-like electrical connection between the upper and lower chambers of the heart, atria and ventricles, respectably).  This accessory pathway is in addition to the AV node, the only normal electrical conductor between the atria and ventricles. 

What causes WPW?

The cause of WPW syndrome is not known.  In most cases it is associated with a structurally and functionally normal heart, though occasionally can be associated with congenital heart disease or heart muscle abnormalities.  

Is WPW passed down from parent to child like other SADS conditions?

It is generally not considered to be hereditary, except in the very rare instance when associated with genetic mutation predisposing to WPW syndrome and hypertrophic cardiomyopathy (HCM).  

What are the symptoms of WPW?

Tachycardia presenting with palpitations and occasionally lightheadedness is the most common symptom.

How is WPW Diagnosed?

• ECG
• Cardiac catheterization with diagnostic electrophysiologic testing

How is WPW Treated?

In contrast to many other types of tachycardias, WPW syndrome can be regarded as potentially “curable” with

• Catheter ablation
• Cryoablation

Indications for electrophysiologic testing vary among physicians and from center to center, but many electrophysiologists now recommend consideration for diagnostic electrophysiology study to risk stratify the accessory pathway electrical properties.  Ablation can be performed in patients who have symptomatic recurrent tachycardias and/or high risk accessory pathway electrical profile. 

WPW Resources

Wolff-Parkinson-White Syndrome Brochure